Protective and immunomodulating influence of supplementing RNA, comparing clinical testing and experimental model.
Project with Grant from the Internal Grant Agency of The Czech Ministry of Health
Registry number: NJ 6888 – 3
Date of research of project: 2001 – 2003
Published: 29. 1. 2004
Health Institute, City of Moskevská
Inadequate nutrition has its big share of health deterioration of the general population, not only by poor eating habits but also by the unbalance of basic nutrition components in food. It is generally calculated fact, that 15-25% of all death is related to improper nutrition.
The optimal presence of vitamins and trace elements in nutrition/food is constantly repeated basic demand, influencing the quality of health of the population. Inadequate composition of nutrition/food influences our immune system analogically just like food deficiency, especially at both sides of the age span of humans, in the period of growth (childhood) and at the period of aging. The present styles/conceptions of the world health policy are based on these ideas/ conclusions. These policies concentrate on preventative programs with the effort to reach possibly the widest parts of the population.
For these reasons, our health policies should include research and clinical verification of different food supplements, in which their positive influence on metabolic, physiologic immune functions has been proven. These aspects are substantially recognized in developed countries, where increased attention is paid to the questions of a food
supplementation with various micronutrients. Japan, the USA, and some European countries have been developing programs for so-called functional food. Lots of the above-mentioned aspects are being closely looked at WHO materials „The Health for all in the 21st century“.
The goal of our project was verification of the possibility to influence the health and immune system by nutrition and supplementing by nutritional products with a high content of DNA. We have explored the effects of highly purified DNA of yeast origin on selected immune parameters, in the experiments and in clinical and preventative studies. We have found that the same result can be achieved by product Imuregen which has a high content of amino acids, polypeptides, oligopeptides, and polynucleotide.
The advantage of this product is very good financial accessibility (the cost for the one-day application is 20x lover than German product “Torula”). We have stated/determined the optimal dose of the supplement in relation to dosage for preventative treatment and dosage for medical treatment. In the aim of the project, we have started from the assumption that immunoregulating effects of the exogenous DNA are very useful for the synthesis of nucleic acids during cell division.
Dietary nucleotides are, from the view of energetic coverage in this application much more suitable also because their partial fission in GI tract leads to their fast absorption and thus to the improved cellular reparation of different tissues of the organism, which ere dependent on supply/feeding of exogenous nucleotides. In many cases, it can be stated that in the importance of nutrition, dietary nucleotides are from this view essential. The absence of dietary nucleotides in human organism can lead even to the symptoms of malnutrition, which is described under the name NAIDS (Nutritionally Acquire Immune Dysfunction Syndromes).
We have tried in our study not only to verify the functionality of supplementation with dietary nucleotide but also their positive effect in preventative and clinical application. In the layout of individual clinical studies, we have surpassed the scope of initial goals, due to the fact, that we have achieved important results with the application of dietary nucleotide in many diseases/illnesses. For this reason, we continue studying the clinical indications/applications further. We recommend the possibility of widespread use of product Imuregen in the form of beverages (which is at the present time produced by the company “Dobra Voda” ) as substantially beneficial to the public.
Due to the fact that the scope of the study was so broad, many other articles/sub-studies will be published during the year 2004. Publications in the Czech Republic and abroad in the English language will be gradually published, some after processing finished stages, others after finishing studies on a sufficient number of followed individuals.
Leader of the project: MUDr. Josef Richter
Co-Researchers: RNDr. Petr Šíma, CSc.
MBÚ Academy of Sciences, Prague
MUDr.Ivan Pfeifer, CSc.
Charles University Prague
RNDr. Vlastimil Král, CSc., Health Institute, City: Ústí nad Labem
MUDr. Dalibor Jílek, CSc., Health Institute, City: Ústí nad Labem
Ing. Ivana Stiborová, Health Institute, City: Ústí nad Labem
MUDr. Stanislava Richterová, Health Institute, City: Ústí nad Labem
Jitka Pešková, Health Institute, City: Ústí nad Labem
MUDr. Dagmar Slížová, Institute of Anatomy LFUK Hradec Králové
Mgr. Lucie Dobiášová, Health Institute, City: Ústí nad Labem