Side Effects of Puberty Blockers

Side Effects of Gender Transition Surgery and Puberty Blockers

Puberty blockers, touted as Gender Affirming Care (GAC), offer transgender youths a way to explore their gender identity allegedly without irreversible side effects.

The practice has been going on for nearly two decades. Pediatric Doctors like Johanna Olson-Kennedy at Children’s Hospital Los Angeles have recommended puberty blockers and other procedures to teenagers since 2007.

However, the lack of comprehensive long-term studies raises concerns, and a growing number of ‘trans‘ have exposed its alleged dangerous long-term side effects. Here are some of the drugs associated with damaging GAC side effects.

In 2023, Dr. Meredithe McNamara of ‘Do No Harm’ testified on a House Committee Hearing about the life long side effects of gender transition surgery and puberty blockers.


Many transgender clinics prescribe bicalutamide, a medication typically used for metastatic prostate cancer, to boys as a puberty blocker and feminizing agent. One of its side effects is the feminization of male bodies, including breast development.

According to Amie Reed, who worked in such a clinic, one of the patients taking Bicalutamide had liver toxicity, a common side effect of cancer drugs.

He was taken off the medication and sent to another hospital unit for evaluation. Later, the patient’s mother sent an electronic message to the Transgender Center, stating that they were fortunate her family was not litigious.

Cancer drugs can be a make or break, although there are food supplementations that do not have adverse side effects.


Goserelin (Zoladex) temporarily halts puberty progression and has been associated with side effects like hot flashes, mood swings, and alterations in sexual development.

Similar to other puberty blockers, it necessitates regular injections for maintenance.


Histrelin (Supprelin LA, Vantas) is employed for puberty suppression, which can cause hot flashes, mood changes, and fatigue. Regular injections are necessary to maintain its effects, and these side effects can impact the individual’s quality of life.


Leuprorelin, commonly known as Lupron, is a medication primarily used as a gonadotropin-releasing hormone receptor agonist. It is often prescribed for conditions like prostate cancer, where it effectively lowers testosterone and estrogen levels.

However, when used for gender-affirming care (GAC), it poses potential dangers. Some individuals have reported severe side effects like cardiovascular issues, impaired metabolism, emotional distress, and reduced bone density due to using Lupron for GAC.

These concerns highlight the need for comprehensive long-term studies and carefully considering its risks in such contexts.

Testosterone side effects

Amie Reed also said that other girls were disturbed by the effects of testosterone on their clitoris, which enlarges and grows into what looks like a microphallus, or a tiny penis.

One patient had an enlarged clitoris that extended below her vulva and rubbed painfully in her jeans. Generally, testosterone therapy has had positive effects, depending on the medical situation.


Triptorelin (Trelstar) is administered through injections and shares common side effects with other puberty blockers, such as hot flashes, mood changes, and fatigue.

The medication requires repeated injections, usually every 1 to 3 months, presenting challenges for consistent management.

Scott Nugent testimony

In 2023, one of the most controversial testimonies against Gender Affirming Care was from a transgender man (biological woman), Scott Newgent.

He questioned insufficient long-term studies, financial motives, and medical involvement. Newgent’s experiences underscore risks like cardiovascular disease, impaired metabolism, and depression resulting from chemical castration.

Nugent has also been taking Laminin supplements to help delay the onset of various diseases associated with his GAC drugs.

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