Laminine & Laminine OMEGA+++ Supplement Clinical Studies Review
Laminine food supplement asserts certain claims based on an independent clinical study that they sponsored. However, the original research papers are not publicly available to support these claims. The white papers on these studies cannot be found on the internet and are only available through LifePharm Global Network, the company that distributes Laminine.
Nonetheless, scientific studies evaluating Laminine’s claims have been published on PDR.net, which provide a comprehensive review of the product’s scientific merits.
Dr. Bjodne Eskeland, a Norwegian scientist and egg research expert, developed YTE or Young Tissue Extract, which is the key ingredient in Laminine’s original formula, and patented it in 1994.
In 2006, he published a summary of the claims of Young Tissue Extract. Laminine contains the second-generation YTE referred to as Fertilized Avian Egg Extract, which Dr. Eskeland formulated for LPGN in 2012.
Claims based on a summary published by PDR.net in 2014
Claims based on Dr. Eskeland’s summary report in 2006
● Effects on libido & depression
● Effects on Stress (Anti-stress)
● Effects on muscle repair
● Effects on hormones
● Effects on wound healing
Laminine on Wound Healing Activity
Reason to believe
The body possesses a natural ability or scheme to heal wounds. However, the larger or more severe the damage, the more time it takes to heal, allowing other elements to disrupt or stop the process. It is only mitigated when help comes in the form of medicine or, in this case, a protein supplement.
Therefore, can protein help heal the wound faster than its usual course?
Well, since the body is made up of proteins, it needs the same ingredient to heal itself but cannot without the help of other properties such as zinc, vitamin C, and signaling molecules to tell the proteins to go where they are supposed to.
This role is mainly taken by the existing adult stem cells in the body.
Laminine’s main ingredient is referred to as YTE or Young Tissue Extract. Although it no longer sources the proprietary YTE from a previous supplier, its version, known as Fertilized Avidan Egg Extract, has a similar nature, form, and function to YTE.
In a 1997 study on YTE, wound bursting pressure was significantly higher in subjects receiving peptide diets than in those just receiving amino acid diets.
Other mechanisms suggested by the authors for the increased wound healing with peptide versus nonpeptide diets include stimulation of collagen synthesis, increased blood flow to the wound, free radical scavenging, and generation of cytokine profiles which better support wound healing.
Laminine on Cortisol (Stress hormone) Study
Reason to believe
The stress hormone cortisol is good for the body, but too much can destroy it. According to a study done by the company and published in PDR.net, 28 participants took part.
The Study claims that an average of 23.7 percent reduced participants’ cortisol levels; 16 started on a higher intake of Laminine—four capsules, twice a day—and 12 began on one tablet twice per day.
Although the Study did not mention if it affects a person who is depressed or has anhedonia, an increase in dopamine (when cortisol is regulated) may help people suffering from depression.
The study was for 12 days, and although the results were very positive, it remains inconclusive because the number of participants and days of trials is still few compared to other “Open-label trials” with an average of 60 to 100 participants, administered at least 30 days.
Reason to doubt
Claiming that it can balance or level high cortisol levels may be valid to some extent, but consistency remains a doubt, given the number of days it was done.
Laminine on Cholesterol and Blood Pressure Studies
Reason to believe
A study conducted by the company combined Laminine (original OPT Blend formula) and their variant, Laminine OMEGA+++. There were 15 individuals in the Study, broken into three groups of five. This was a double-blind, placebo-controlled study that took place over a total period of 12 weeks.
The objective is to prove that combining Laminine and Laminine OMEGA+++ can lower cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL), triglycerides, and blood pressure.
The study had two phases. The first was eight weeks and included Groups A, B, and C. Participants took four supplements daily—two in the morning and two in the evening.
The second phase included participants from Group A, which took an additional four weeks. During phase 2, participants in Group A consumed eight supplements a day—four in the morning and four in the evening.
During the study’s first phase, results showed that the average cholesterol drop in Group B was about 9.8 percent, compared to 11.5 percent in Group C.
Meanwhile, cholesterol levels in Group A increased by 1.0 percent over the first eight weeks but dropped by 12 percent between weeks eight and 12. Results for LDL and triglycerides generally followed a similar pattern.
On Triglyceride levels
Triglyceride levels in Group A dropped by 267 mg/dl or 58.2 percent during Phase II, the most substantial change throughout the Study. However, participants in Group C experienced the best and most consistent overall results.
HDL levels were within normal limits at the beginning and end of the Study for all participants. According to their customer review, taking high dosages for individuals with high triglycerides resulted in improvement.
Did it work to lower cholesterol and triglyceride levels?
Based on this data, we can assume that Laminine OMEGA+++ helps to lower cholesterol, LDL and triglyceride, and blood pressure levels (Group B).
Still, when taken with Laminine, the decreases are more significant (Group C after Phase I and Group A after Phase II).
Although participants in Group A took double the Laminin and Laminine OMEGA+++ during Phase II, results were not drastic enough to recommend doubling the suggested usage for Laminine OMEGA+++ for all individuals.
The decrease in LDL was not significant in Group A during Phase II compared to Group C during Phase I.
Side effects of the Study
Although the trial was focused on cholesterol, participants were also asked to indicate if there were any effects or improvements on their joints, memory, Skin, Sexual Drive, Muscle Tone, strength, stress, sleep emotional well-being.
Only four of the five subjects in Group A chose to participate in the survey.
After Phase II, the average improvement in all categories was about 5.75 on a scale of 0-10, with zero representing no change and 10 representing a significant improvement. These are subjective results but notable.
However, this forms part of a survey and should not be deemed a clinical study as no scientific data supports the claim.
Most of these can be seen as placebo effects or generally ruled out as positive side effects when a person suffers from protein deficiency, where amino acids greatly help.
The bottom line is, Laminine is beneficial for prediabetic persons, the study reveals. [Prediabetic supplement]
Reason to doubt
The claim of LifePharm Global Network that it can help lower cholesterol and triglyceride levels in a person taking both Laminine and Laminine OMEGA+++ is relatively new in the health supplement industry.
It isn’t easy to ascertain the result because the complete Study is unavailable. We are only relying on what was seen as positive.
The number of days for the trials is also short and may prove inconclusive unless the number of participants can be increased or doubled at the very least.
Nevertheless, the effect was clearly illustrated, but sustainability or if it can apply to everyone remains to be seen, despite known side-effects of Laminine.