Imuregen and Immunity Functions
It was repeatedly proved that IMUREGEN increases specific and non-specific immune functions, proliferation activity of lymphoid cells with the consequent corresponding reaction of both cell and humoral immune response. Administration increases not only numbers but first of all the activity of natural killers, production of some cytokines. This may be used for reparation of tumorous conditions during and after conventional therapy.
The significant effect of IMUREGEN is proved towards the parameters of humoral immunity, including B lymphocytes-regulated production of antibodies together with increased resistance to bacterial and viral infections. Endogenous nucleotides positively influence antibody response and keep its optimal function. A significant influence on levels of antibodies against tetanus in vaccinated children population was proved. In comparison with the control group there were statistically significant differences in antibody responses.
Repeatedly was proved the protective effect of IMUREGEN in the therapy of mycotic infections. Nucleotides influence mechanisms of cellular immunity. They speed up lymphoproliferation induced by alloantigen, correct immunosuppression induced by malnutrition, increase the number of NK cells and their activity. They increase the production of IL-2 and take part in the increase in the number of macrophages and at the same time they increase their fagocytary activity. It is proved that IMUREGEN increases the proliferation of bone marrow and proliferation of peripheral neutrophils.
Administration of IMUREGEN increases resistance against infections both in animal models and humans. In an experimental model was proved significant resistance to infections caused by Candida albicans and Staphylococcus aureus. The survival of exposed animals was statistically significant in comparison with the control group.
IMUREGEN adjusts the ratio of cellular subpopulations Th1 and Th2 and in such way significantly decreases the risk of sensibilization and induction of IgE response. Already 0.5 % of dNT contained in IMUREGEN proved a reduction of induction risk of allergic symptoms in the experimental model of inhalation allergy. It was proved that the administration of IMUREGEN to premature children was connected with a significant increase of CD4+ lymphocytes.
IMUREGEN and secretory immunity
Long term administration of IMUREGEN results in a positive influence on factors of mucosal immunity. It was revealed, that there is an increase of secretory IgA, a significant decrease of albumin and C-reactive protein together with overall recovery. In groups with physical load, IMUREGEN induced an increase of secretory IgA, IgG, and IgM in saliva. In comparison with the placebo group, there was an increase of mucosal lysozyme levels and so provision of higher resistance to infectious load.
Dietary nucleotides in IMUREGEN influence generally production of antibodies via T-helpers and the earliest phase of antigen presentation. The immune response is regulated by interaction with T regulation cells. In repeated studies, following health conditions of children hospitalized in a sanatorium for pulmonary and allergic diseases we revealed that after 1 month of IMUREGEN administration there was not only significant improvement of secretory immune response represented by an increase of SIgA, salivatory IgG and lysozyme together with the decrease of salivatory C-reactive protein. Moreover, there was a significant decrease of cortisol in saliva representing a normalization of the stress response.
There was not only significant improvement of respiratory functions of followed children with a decrease of levels eNO by 15%, besides that there was the improvement of the physical condition represented by increased endurance. Measured entrance values of the 6-minute walk test were increased after a stay in a sanatorium by 17%. Control testing showed the persistence of positive findings during 6 months, slow worsening reflected mostly staying in an environment contaminated with exhaust gases, chemicals, products of local stoves and in more than 50% of cases there was exposition to indoor contaminants (smoking parents).
Reference: Nucleotides Comprehensive Independent Report