The Immunity Functions of Nucleotide
Reference: Nucleotides Comprehensive Independent Report
IMUREGEN supplement alleged that it increases specific and non-specific immune functions. Such as the proliferation of lymphoid cells with the consequent corresponding reaction of both cell and humoral immune response. Taking nucleotide increases the activity of some cytokines. Thus, it may be used as a reparation of tumorous conditions. Particularly, the B lymphocytes, the regulated production of antibodies together with increased resistance to bacterial and viral infections.
In addition, nucleotide influence the mechanisms of cellular immunity. They speed up lymphoproliferation induced by alloantigen, correct immunosuppression induced by malnutrition. It also increases the number of NK cells and their activity which increases the production of IL-2. It takes part in the increase in the number of macrophages and at the same time they increase their fagocytary activity. Thus, it may help with the proliferation of bone marrow and peripheral neutrophils.
Taking IMUREGEN may resistance against infections in both animals and humans. Particularly, an experiment (with animals) showed significant resistance to infections caused by Candida albicans and Staphylococcus aureus.
IMUREGEN adjusts the ratio of cellular subpopulations Th1 and Th2 and in such way significantly decreases the risk of sensibilization and induction of IgE response. In humans, premature children given a liquid dose of IMUREGEN had a significant increase of CD4+ lymphocytes.
Dietary nucleotides in IMUREGEN influence generally production of antibodies via T-helpers and the earliest phase of antigen presentation. The immune response is regulated by interaction with T regulation cells. In repeated studies, after 1 month of taking IMUREGEN, there was an increase of SIgA, salivatory IgG and lysozyme together with the decrease of salivatory C-reactive protein. Moreover, there was a significant decrease in cortisol in saliva representing a normalization of the stress response.
There was not only significant improvement of respiratory functions of followed children with a decrease of levels eNO by 15%, besides that there was the improvement of the physical condition represented by increased endurance. Measured entrance values of the 6-minute walk test were increased after a stay in a sanatorium by 17%.
Control testing showed the persistence of positive findings during 6 months, slow worsening reflected mostly staying in an environment contaminated with exhaust gases, chemicals, products of local stoves and in more than 50% of cases there was exposition to indoor contaminants (smoking parents).